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NMDA receptor is a glutamate and ion channel protein receptor that is activated when glycine and glutamate bind to it. The receptor is a heteromeric complex that interacts with multiple intracellular proteins by three different subunits: NR1, NR2 and NR3. The BCl-2-family protein
inhibitors represent one of the most successful examples of helix-groove binders, inhibiting the interaction between the BCl-2 proteins and the BH3 domains (alpha-helical domains) of pro-apoptotic proteins [138].Among these
inhibitors, it is worth highlighting ABT-263 [139] (
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