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An artery is made up of several layers: an inner lining called the endothelium, an elastic membrane that allows the artery to expand and contract, a layer of smooth muscle, and a layer of connective tissue. Relationship of glycemia control to lipid and blood pressure lowering and atherosclerosis: the SANDS experience There are a variety of ways that statins differ. One of the differences involves potency in the ability to reduce cholesterol plasma levels. Rosuvastatin and atorvastain are the most potent statins with respect to lowering LDL, followed by simvastatin and pravastatin ().. Statins also differ in how strongly they interact with other drugs; this is due to drug metabolism. 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