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Two theories of the direct initiation of apoptotic mechanisms in mammals have been suggested: the TNF-induced (tumor necrosis factor) model and the Fas-Fas ligand-mediated model, both involving receptors of the TNF receptor (TNFR) family coupled to extrinsic signals.. TNF path. TNF-alpha is a cytokine produced mainly by activated macrophages, and is the major extrinsic mediator of apoptosis. A UMD researcher has uncovered new mechanisms that dictate the development of germline stem cells or germ cells, the only cell type capable of passing genetic information on to the next generation. Kærlighedens glæde Tract 90: On Certain Passages in the 39 Articles. 1841 The vast range of maximum lifespan differences between species provides convincing evidence that longevity is genetically influenced. 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