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Bind 3 Oct-4 (octamer-binding transcription factor 4), also known as POU5F1 (POU domain, class 5, transcription factor 1), is a protein that in humans is encoded by the POU5F1 gene. Oct-4 is a homeodomain transcription factor of the POU family.It is critically involved in the self-renewal of undifferentiated embryonic stem cells. As such, it is frequently used as a marker for undifferentiated cells. Engineering By Design Engineering By Design Body Systems in Papua New Guinea Engineering By Design Engineering By Design The Penguin Classic Crime Omnibus The Penguin Classic Crime Omnibus The Penguin Classic Crime Omnibus Engineering By Design The Penguin Classic Crime Omnibus Engineering By Design As a human embryo develops, its cells become progressively restricted in the types of specialized cells that they can produce. Inner cell mass (ICM) cells of the blastocyst can make any type of body cell. Cloning. 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