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The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress. It is a stress response that has been found to be conserved between all mammalian species, as well as yeast and worm organisms. This article focuses on the mammalian response. The UPR is activated in response to an accumulation of unfolded or misfolded proteins in the lumen of ... download Protein Quality Control In Neurodegenerative Diseases kindle The VigilanteS Bride The study of protein misfolding and aggregation saw resurgence in the last decade. Aggregation is the main cause of several human neurodegenerative diseases which makes this field as the leading edge in the science today. 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