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Those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal ... Colistin, also known as polymyxin E, is an antibiotic produced by certain strains of the bacteria Paenibacillus polymyxa.Colistin is a mixture of the cyclic polypeptides colistin A and B and belongs to the class of polypeptide antibiotics known as polymyxins.Colistin is effective against most Gram-negative bacilli.. Colistin is a decades-old drug that fell out of favor in human medicine due to ... 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