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oxidative stress has been increasingly recognized as a contributing factor
in aging and in various forms of pathophysiology generally associated with
aging.Our view of
oxidative stress has been largely “superoxide-centric”, as we focused on the pathological sources of this oxygen-derived free radical and the types of molecular havoc it can wreak, as well as on ...
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free radical theory of aging was conceived by Denham Harman in the 1950s, when prevailing scientific opinion held that free radicals were too unstable to exist in biological
systems. This was also before anyone invoked free radicals as a cause of degenerative
diseases. Two sources inspired Harman: 1) the rate of living theory, which holds that lifespan is an inverse function of ...
Distrito Nueve Tiger Fry and Other Tales Level 1 You can beat depression Hormesis is any process in a cell or organism that exhibits a biphasic response to exposure to increasing amounts of a substance or condition. Within the hormetic zone, there is generally a favorable biological response to low exposures to toxins and other stressors.
Hormesis comes from Greek hórmēsis "rapid motion, eagerness", itself from ancient Greek hormáein "to set in motion, impel ...
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Mitohormesis, a different form of hormesis than that discussed in the previous blog entry Radiation Hormesis.
Mitohormesis has to do with cell metabolic pathways and
oxidative stress, topics I have discussed in many previous blog entries. The proper functioning of
mitohormesis has to do with multiple aspects of health and with extended organism longevity ... Extensive research during the past 2 decades has revealed the mechanism by which continued
oxidative stress can lead to chronic
inflammation, which in turn could mediate most chronic
diseases including cancer, diabetes, and cardiovascular, neurological, and pulmonary
diseases.
Oxidative stress is a normal phenomenon in the body. Under normal conditions, the physiologically important intracellular levels of reactive oxygen species (ROS) are maintained at low levels by various enzyme
systems participating in the in vivo redox homeostasis. Therefore,
oxidative stress can also be viewed as an imbalance between the prooxidants and antioxidants in the body.
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