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Morpholino, also known as a
Morpholino oligomer and as a phosphorodiamidate
Morpholino oligomer (PMO), is a type of oligomer molecule (colloquially, an oligo) used
in molecular biology to modify gene expression.Its
molecular structure has DNA bases attached to a backbone of methylenemorpholine rings linked through phosphorodiamidate groups. Morpholinos block access of …
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microRNA (abbreviated
miRNA) is a small non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression. miRNAs function via base-pairing with complementary sequences within mRNA molecules. As a result, these mRNA molecules are silenced, by one or more …
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world as I remember it Plan And Make Your Own Fences Gates Walkways Walls Drives 3.2. miR-503-3p Inhibits Colony-Forming Activity in Cancer. Among the miRNAs, identified within the exosomes, miR-503-3p can regulate cell proliferation and apoptosis via direct targeting to p21, resulting in inhibition of cancer growth. Additionally, the cell-cycle inhibitor P21 is crucial for the self-renewal of leukemia stem cells [].Whole exosomes, isolated from ASCs, inhibited the cell ...
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METHODS: The
miRNA expression profile GSE7072, which includes three RB samples and three healthy retina samples, was used.After data normalization using the preprocessCore package, differentially expressed miRNAs …
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