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Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. En hjertesag 100 pulserende år med Turistforenignen for Viborg og O... In clinical trials, a surrogate endpoint (or surrogate marker) is a measure of effect of a specific treatment that may correlate with a real clinical endpoint but does not necessarily have a guaranteed relationship. The National Institutes of Health (USA) defines surrogate endpoint as "a biomarker intended to substitute for a clinical endpoint".. Surrogate markers are used when the primary ... 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More generally a biomarker is anything that can be used as an indicator of a particular disease state or some other physiological state of an organism.. A biomarker can be a substance that is introduced into an organism as a means to examine organ function or other aspects of health. 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