MANUAL OF POLICIES AND PROCEDURES CENTER FOR DRUG EVALUATION AND RESEARCH MAPP 5015.8 . Originating Office:
Office of Pharmaceutical Quality Effective Date: 3/9/2009; Recertification 4/22/2014; 6 ... Under the General Notices, manufacturers may use alternative methods if those methods are validated. Ultimately, the
solvents known to be present in the product should be controlled before it goes to market. More than two-thirds of young substance abusers suffer from mental
health problems, such as anxiety, depression, ADHD, and eating disorders. As a rule, substance abuse and mental
health issues ... From the 1950s through the 1980s, people living or working at the U.S. Marine Corps Base
Camp Lejeune, North Carolina, were potentially exposed to drinking water contaminated with industrial
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Inhalant use; Common household products such as nail polish contain
solvents that can be concentrated and inhaled, in a manner not intended by the manufacturer, to produce intoxication.
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Health hazards associated with solvent exposure include toxicity to the nervous system, reproductive damage, liver and kidney damage, respiratory impairment, cancer, and dermatitis.
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issues include solvent safety in dry cleaning and machinery safety in laundries, with some laundry machines presenting severe burning hazards.
Solvents are among the most commonly used chemicals in workplaces. Workers in different jobs regularly use
solvents for degreasing, metal cleaning, and adhesion and as paint thinners or lubricants.
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Solvents, also known as VOCs (volatile organic compounds), are used in many construction products such as paints, thinners and glues.
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