The first formal report of the pain-relieving properties of capsaicin appeared in 1850 [1]. However, for centuries before this, capsaicin-containing extracts had been used as folk medicines in cultures with access to pepper plants, much in the same way as poppy or willow-bark extracts were.
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Turning up the Heat
on Pain: TRPV1 Receptors in Pain and Inflammation
(Progress in Inflammation Research) 2005th Edition
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Turning up the heat
on pain : TRPV1 receptors in pain and inflammation. [Annika B Malmberg; Keith R Bley;] -- Vanilloids mediate their effects by selective agonism of an ion channel, the vanilloid receptor 1 (TRPV1). TRPV1 is a ligand-gated, non … Since then, capsaicin and related vanilloid c- pounds have played a prominent role in analgesia and inflammation investigations because of their ability to selectively activate a subpopulation of sensory neurons and produce sensations of pain and localized erythema.
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